A Novel Acid‐Degradable PEG Crosslinker for the Fabrication of pH‐Responsive Soft Materials
نویسندگان
چکیده
The design and synthesis of a novel acid-degradable polyethylene glycol-based N-hydroxysuccinimide (NHS) ester-activated crosslinker is reported. reactive towards nucleophiles features central ketal functional group that stable at pH > 7.5 rapidly hydrolyses 6.0. used to (i) fabricate polysaccharide hydrogels exhibit controlled degradation upon exposure an acidic environment or via endogenous enzyme activity; (ii) construct hydrogel-filled protein-polymer microcompartments (termed proteinosomes) capable pH-dependent membrane disassembly. Taken together the results provide new opportunities for fabrication pH-responsive soft materials with potential applications in drug delivery, tissue engineering, soft-matter bioengineering.
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ژورنال
عنوان ژورنال: Macromolecular Rapid Communications
سال: 2021
ISSN: ['1022-1336', '1521-3927']
DOI: https://doi.org/10.1002/marc.202100102